Creatinine and cystatin C: Shooting at a flying target

Creatinine and cystatin C: Shooting at a flying target

I read with great interest the article entitled ‘Significant differences when using creatinine, modification of diet in renal disease, or cystatin C for estimating glomerular filtration rate in ICU patients’ by Lipcsey et al. (1) in the March 2011 issue of the Upsala Journal of Medical Sciences. This article provides an interesting analysis of estimating renal function in critically ill patient...

Cystatin C versus creatinine in renovascular disease.

Glomerular filtration rate determination by creatinine and cystatin-C in patients with acute pyelonephritis

Background: Measurement of glomerular filtration rate (GFR) and monitoring of it in any patient on nephrotoxic drugs is very important. Recently, cystatin C (cys-C) has been introduced as a better marker for determining and monitoring renal function than creatinine especially in a mild decrease of GFR. This study was done to assess the change of GFR measurement based on serum Cys-C and creatini...

Cystatin C versus creatinine-based GFR formula in CKD patients

Introduction. Glomerular Filtration Rate (GFR) is the main tool to assess kidney function. Some experts suggest cystatin C as a more precise and accurate indicator than creatinine to calculate GFR. This study is designed to assess if cystatin C is more helpful in early diagnosis and better follow-up of Chronic Kidney Disease (CKD) patients who may benefit more from appropriate and timely manage...

More evidence that cystatin C predicts mortality better than creatinine.

podocin facilitates nephrin signaling. J Biol Chem 276: 41543–41546, 2001 7. Huber TB, Simons M, Hartleben B, Sernetz L, Schmidts M, Gundlach E, Saleem MA, Walz G, Benzing T: Molecular basis of the functional podocin-nephrin complex: Mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet 12: 3397–3405, 2003 8. Huber TB, Schermer B, Muller RU, Hohne M, Ba...